11-deoxycorticosterone

Deoxycorticosterone acetate（DOCA）是一种由肾上腺产生的类固醇激素，具有盐皮质激素活性，是醛固酮的前体。DOCA 是一种矿化皮质激素受体激动剂，可导致严重的肾脏损伤，包括炎症、纤维化、肾小球损伤和蛋白尿，常用于诱导慢性肾损伤以及高血压动物模型。

11-Deoxycorticosterone-d8 是 11-Deoxycorticosterone 的氘代化合物。11-Deoxycorticosterone 的 CAS 号为 64-85-7。Deoxycorticosterone 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。

Tetrahydro 11-Deoxycorticosterone-d3 是 Tetrahydro 11-Deoxycorticosterone 的氘代化合物。Tetrahydro 11-Deoxycorticosterone 的 CAS 号为 567-03-3。

Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) 是一种有效的 GABAA 受体正变构调节剂 (PAM)，具有神经保护活性， 选择性抑制神经类固醇介导的 GABA 诱发电流在 GABAA 受体上的增强，可用于研究神经疾病。

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。

Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.

21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722)为11-酮孕酮的一种皮质类固醇代谢产物。该化合物通过11-酮孕酮经细胞色素P450 (CYP)酶CYP17A1的作用生成，也可由21-脱氧皮质醇通过11β-羟基类固醇脱氢酶2型 (11β-HSD2) 的氧化反应形成。在先天性肾上腺增生症患者中，由于缺乏21-羟化酶，21-Deoxy Cortisone 的水平会出现上升，此症状为该遗传代谢缺陷的表现之一。