11-deoxycorticosterone

Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。

11-Deoxycorticosterone-d8 是 11-Deoxycorticosterone 的氘代化合物。11-Deoxycorticosterone 的 CAS 号为 64-85-7。Deoxycorticosterone 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。

Tetrahydro 11-Deoxycorticosterone-d3 是 Tetrahydro 11-Deoxycorticosterone 的氘代化合物。Tetrahydro 11-Deoxycorticosterone 的 CAS 号为 567-03-3。

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb db mouse model of type 2 diabetes.

Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。

Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.

Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) 是一种有效的 GABAA 受体正变构调节剂 (PAM)，具有神经保护活性， 选择性抑制神经类固醇介导的 GABA 诱发电流在 GABAA 受体上的增强，可用于研究神经疾病。

21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722)为11-酮孕酮的一种皮质类固醇代谢产物。该化合物通过11-酮孕酮经细胞色素P450 (CYP)酶CYP17A1的作用生成，也可由21-脱氧皮质醇通过11β-羟基类固醇脱氢酶2型 (11β-HSD2) 的氧化反应形成。在先天性肾上腺增生症患者中，由于缺乏21-羟化酶，21-Deoxy Cortisone 的水平会出现上升，此症状为该遗传代谢缺陷的表现之一。