γ-glutamylcysteine synthetase

L-Buthionine-(S,R)-sulfoximine 是一种 γ-谷氨酰半胱氨酸合成酶抑制剂，具有细胞渗透性、不可逆性和快速起效性。L-Buthionine-(S,R)-sulfoximine 通过消耗 GSH 诱导细胞中的氧化应激。

γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.1It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelatins, the heavy metal detoxifying enzymes in plants.2

DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) 是 γ-谷氨酰半胱氨酸合成酶的抑制剂，用于治疗实体瘤。

L-Buthionine-(S,R)-sulfoximine hydrochloride 是一种有效的、可细胞渗透的，作用快的 G-谷氨酸半胱氨酸合成酶 (γ-glutamylcysteine synthetase, γ-GCS)的不可逆抑制剂并可耗尽细胞内的谷胱甘肽水平，在黑色素瘤、乳腺癌和卵巢癌标本上的 IC50值分别为1.9 μM、8.6 μM 和 29 μM。