β amyloid (1 20)

This synthetic peptide consists of amino acids 1 to 20 of beta amyloid protein.

(Glu20)-Amyloid β-Protein (1-42) 是一种具有 Glu20 突变的淀粉样蛋白β (Aβ) 变体，该变体的原纤维化速度较慢。此突变能够减少 Aβ 的聚集倾向，进而阻止缓慢原纤化肽的累积。它是阿尔茨海默病中血管及脑内淀粉样沉积物的关键组成部分。

Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM. In vivo, intracerebral injection of Aβ (25-35) (20 nmol) in rats induces lesions of neuronal and tissue loss. Aggregated Aβ (25-35) administered intracerebroventricularly to rats induces learning and memory impairments in the Y-maze, novel object recognition, and contextual fear conditioning tests.

β-Amyloid peptide(16-20)，即 Amyloid-β(Abeta) 的氨基酸序列(KLVFF)部分，有效抑制 Abeta 原纤维形成，通过在 N 和 C 末端添加 RG- -GR-NH2 残基增强其溶解性。

Acetly-β Amyloid (15-20), Amide 为多肽片段，具有抑制 Aβ (1–40) 肽β-折叠形成并稳定其结构的功能，适用于阿尔茨海默病的相关研究。