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IL-3 Protein, Human, Recombinant(aa 20-152)

产品编号 TMPY-00297

别名: interleukin 3, 白介素, 白细胞介素, Interleukin-3, IL-3, MCGF, MULTI-CSF

IL-3 Protein, Human, Recombinant(aa 20-152) is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P08700.

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IL-3 Protein, Human, Recombinant(aa 20-152)

规格	价格/CNY		货期	数量
20 μg	￥ 1,550		现货
100 μg	￥ 3,930		5日内发货

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参考文献

生物活性	1.Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.15-0.75 ng/ml. 2.Loaded Human IL-3R alpha Protein, His Tag on His1K Biosensor, can bind Human IL3 protein with an affinity constant of 0.183 μM as determined in BLI assay (Routinely tested).
产品描述	IL-3 Protein, Human, Recombinant(aa 20-152) is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P08700.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	P08700
别名	interleukin 3, 白介素, 白细胞介素, Interleukin-3, IL-3, MCGF, MULTI-CSF
蛋白构建	The Human IL3 (NP_000579.2) (Ala20-Phe152) was expressed with an initial Met.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	15.2 kDa (predicted)

内毒素	< 5 EU/mg of the protein.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation, and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

参考文献

1. Meyer CG,et al.. (2011) IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. Hum Mol Genet. 20(6):1173-81. 2. Zambrano A,et al.(2010) IL-3 controls tau modifications and protects cortical neurons from neurodegeneration. Curr Alzheimer Res. 7(7):615-24. 3. Dentelli P,et al.. (2011) IL-3 is a novel target to interfere with tumor vasculature. Oncogene. 30(50):4930-40.

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Keywords

IL-3 Protein, Human, Recombinant(aa 20-152) interleukin 3 白介素白细胞介素 Interleukin-3 IL-3 MCGF MULTI-CSF IL 3 IL3 recombinant recombinant-proteins proteins protein

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