Salvinorin A

Name: Salvinorin A
Brand: TargetMol
SKU: T23306
Price: 2790 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.06%

货号 T23306Cas号 83729-01-5

别名 丹酚 A

Salvinorin A 是一种非含氮 κ-opioid 样物质选择性激动剂。

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Salvinorin A

一键复制产品信息

很棒

纯度: 99.06%

货号 T23306 别名 丹酚 ACas号 83729-01-5

Salvinorin A 是一种非含氮 κ-opioid 样物质选择性激动剂。

规格	价格	库存
1 mg	¥ 2,790	现货
5 mg	¥ 6,620	现货
10 mg	¥ 8,990	现货
25 mg	¥ 13,300	现货
50 mg	¥ 17,900	现货
100 mg	¥ 23,900	待询
1 mL x 10 mM (in DMSO)	¥ 7,180	现货

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产品介绍

Salvinorin A AI Summary

Salvinorin A exhibits potent bioactivity primarily at the kappa opioid receptor (KOR), showing high affinity and selectivity for this receptor over mu and delta opioid receptors. It has a Ki value as low as 1.3 nM indicating strong binding affinity, and demonstrates agonist activity with EC50 values ranging from 0.03 nM to 45.0 nM in various assays. The compound achieves high efficacy in stimulating [35S]GTP-gamma-S binding and inhibiting cAMP accumulation, with Emax values up to 120.0%. In in vivo studies, it shows significant antinociceptive effects in mouse models with ED50 values of 0.59 mg/kg in the p-phenylquinone writhing assay and 1.98 mg/kg in the tail flick assay. Apart from its activity at KOR, Salvinorin A displays low activities at the delta and mu opioid receptors with Ki values exceeding 1000.0 nM and 5790.0 nM respectively. This selective activity profile makes Salvinorin A a promising candidate for developing therapies targeting KOR-related pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Salvinorin A is a non-nitrogenous κ-opioid selective agonist.
别名	丹酚 A

化学信息

分子量	432.46
分子式	C₂₃H₂₈O₈
CAS No.	83729-01-5
Smiles	C[C@@]12[C@@]3([C@](C)([C@H](C(OC)=O)C[C@H](OC(C)=O)C3=O)CC[C@]1(C(=O)O[C@@H](C2)C=4C=COC4)[H])[H]
密度	1.28 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (63.59 mM), Sonication is recommended.

Ethanol: Soluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3124 mL	11.5618 mL	23.1235 mL	115.6176 mL
5 mM	0.4625 mL	2.3124 mL	4.6247 mL	23.1235 mL
10 mM	0.2312 mL	1.1562 mL	2.3124 mL	11.5618 mL
20 mM	0.1156 mL	0.5781 mL	1.1562 mL	5.7809 mL
50 mM	0.0462 mL	0.2312 mL	0.4625 mL	2.3124 mL