n. gonorrhoeae

Rosoxacin (Acrosoxacin) 是具有口服活性的喹诺酮类抗生素，具有广谱的抗菌活性，抑制革兰氏阴性菌，包括淋病奈瑟氏球菌(MIC90=0.03 mg ml)。它在尿路感染中有应用的潜能。

Spiramycin (Rovamycin) 是一种由安博链霉菌产生的大环内酯类抗生素，具有抗细菌和弓形虫活性，并具有抗寄生虫作用。它由 16 个内酯环组成，其上附着 mycaminose，forosamine 和 mycarose 三种糖。

Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg mL，0.03-0.12 mg mL 和 0.015-0.12 mg mL。

BLP-3是一种在X. laevis皮肤中表达的内源性多肽，具有抗菌特性。在20 µg ml的浓度下对N. meningitidis、N. gonorrhoeae、N. lactamica和N. cinerea有效。BLP-3折叠成α-螺旋结构，能插入并破坏类细菌膜。

ω-azido-C6 Ceramide 能降低膜电位，并对Neisseria 展现抗菌活性，其中对 N. meningitidis MC58 和 N. gonorrhoeae FA1090 的最小抑制浓度（MIC）均为 2 µg mL。

Leucomycin A4 is a macrolide antibiotic that has been found in S. kitasatoensis. It is active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 μg/ml, respectively).

TP0480066, a selective topoisomerase II inhibitor, demonstrates excellent inhibitory activity against DNA gyrase (IC50 = 1.10 nM) and topo IV (IC50 = 62.89 nM). This compound exhibits potent efficacy against multiple bacterial species, including drug-resistant strains. Moreover, TP0480066 displays significant inhibitory activity against N. gonorrhoeae, making it suitable for research on gonorrhea [1] [2].