RD0448 is an inhibitor of DYRK1A, DYRK1B, and DYRK2. It selectively targets the non-native (folding intermediate) states of DYRK1A and DYRK1B, with its binding site remaining concealed under native conditions, thus acting as a stabilizing agent that tightly binds and forms a stable complex with slow dissociation. In contrast, RD0448 targets the native state of DYRK2 without preference for its non-native state, acting as a weak binder that results in a rapidly dissociating complex [1].

DYRK1A:>64 μM