Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Procyclidine (Tricyclamol; (±)-Procyclidine) 是一种抗胆碱能剂。它是一种毒蕈碱受体 (muscarinic receptor) 拮抗剂,也是 N-甲基-D-天冬氨酸 (NMDA) 拮抗剂。Procyclidine 可用于帕金森症和相关精神疾病的研究,如Soman 诱发的癫痫。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent which is a muscarinic receptor antagonist as well as an N-methyl-D-aspartate ( NMDA ) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders, for example, Soman-induced epilepsy [1] [2]. |
体内活性 | Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether [1]. Animal Model: Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs [1] Dosage: 0.3-6.0 mg/kg Administration: Subcutaneous injection; once Result: Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively. Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus. |
分子量 | 287.44 |
分子式 | C19H29NO |
CAS No. | 77-37-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Procyclidine 77-37-2 Inhibitor inhibitor inhibit