Name: PDI2
Brand: TargetMol
SKU: TP4364
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	PDI2 (PSMA-DOTA-PEI2) is a ligand for prostate-specific membrane antigen (PSMA) that functions as a tumor retention agent, a reducer of renal uptake, an imaging agent, and an antitumor agent for SPECT diagnostic imaging and radiotherapy. It specifically binds to PSMA on prostate cancer cells and enters cells through clathrin-dependent endocytosis, resulting in higher tumor retention and reduced renal uptake. PDI2 is applicable in research involving prostate cancer and castration-resistant metastatic prostate cancer.
体外活性	[111 In]In-PDI2（0.195-50 nM；冰上孵育 2 h）能够特异性结合于LNCaP细胞上的PSMA，K d值为22.8 nM。[111 In]In-PDI2（37 kBq；冰上结合2 h，37℃ 孵育0-4 h）在LNCaP细胞中的内化率达38.9%。
体内活性	PDI2（111 kBq；i.v.；单剂量）在PSMA阳性LNCaP前列腺癌异种移植模型中显示出较高且持久的肿瘤摄取，并具有良好的肿瘤/肾脏放射性比值。PDI2（5-10 kBq；i.v.；单剂量）可显著抑制PSMA阳性LNCaP前列腺癌异种移植物生长，且未见明显毒性。
别名	PSMA-DOTA-PEI2

化学信息

分子量	1271.41
分子式	C₅₉H₉₀N₁₂O₁₉
CAS No.	3110124-60-9
Smiles	C([C@H](NC(=O)[C@H]1CC[C@H](CNC(CCC(C(O)=O)N2CCN(CC(O)=O)CCN(C(CCC(NCCNCCN)=O)C(O)=O)CCN(CC(O)=O)CC2)=O)CC1)C(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C3=CC4=C(C=C3)C=CC=C4

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

PDI2