Name: Olamufloxacin
Brand: TargetMol
SKU: T218985
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述	Olamufloxacin (HSR-903) is an orally active fluoroquinolone antibacterial agent. It exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Olamufloxacin can inhibit the growth of extracellular Legionella spp. bacteria and the intracellular growth of Legionella pneumophila. It reduces cytotoxicity caused by intracellular proliferation of Legionella pneumophila and increases the survival rate of guinea pigs infected with this bacterium, while also decreasing the bacterial load in their lungs. Olamufloxacin is used in the study of Legionnaires' disease.
体外活性	Olamufloxacin (2 days) 在体外能有效抑制 81 株军团菌 (Legionella spp.) 的生长，MIC 50 为 0.008 mg/L，MIC 80 和 MIC 90 为 0.032 mg/L，几何平均 MIC 为 0.0244 mg/L。Olamufloxacin (0.008-0.032 mg/L; 3 days) 抑制 J774.1 巨噬细胞中嗜肺军团菌 SG1 80-045 的胞内生长。Olamufloxacin (0.004 mg/L; 72 h) 可抑制细胞内嗜肺军团菌 SG1 80-045 对 J774.1 巨噬细胞的致细胞病变作用。
体内活性	Olamufloxacin (1.25-5 mg/kg；口服；每日 2 次；2-7 天) 可在嗜肺军团菌感染豚鼠中提高生存率，并降低肺部细菌负荷。
别名	欧拉沙星, HSR-903

化学信息

分子量	386.42
分子式	C₂₀H₂₃FN₄O₃
CAS No.	167887-97-0
Smiles	N[C@H]1C2(CN(C1)C=3C(C)=C4N(C=C(C(O)=O)C(=O)C4=C(N)C3F)C5CC5)CC2

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Olamufloxacin