Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NV-5138 hydrochloride 是一种亮氨酸类似物,是一个具有选择性和口服活性的脑内的mTORC1的激动剂,可与 Sestrin2 结合。NV-5138 hydrochloride 可用于抗抑郁的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 8,620 | 10-14周 | ||
50 mg | ¥ 11,200 | 10-14周 | ||
100 mg | ¥ 16,200 | 10-14周 |
NV-5138 hydrochloride 的其他形式现货产品:
产品描述 | NV-5138 hydrochloride is a leucine analog and is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride can be used in the research of antidepressants [1] [2]. |
体内活性 | NV-5138 is found to have essentially 100% orally bioavailable with an elimination half-life in plasma of approximately 3 h determined following intravenous and oral dosing in rats [1]. NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC [2]. NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects [2]. Animal Model: Male Sprague-Dawley rats weighing 250-260 g [2]. Dosage: 40, 80, 160 mg/kg. Administration: PO, single dose (160 mg/kg) or daily for a total of 7 days (40, 80 mg/kg). Result: Produced antidepressant effects. Animal Model: Male Sprague-Dawley (SD) rats weighed 250-400 g [1]. Dosage: 1 mg/kg, 5 mg/kg ( Pharmacokinetic Design ). Administration: I.V at 1 mg/kg and PO at 5 mg/kg. Result: Essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h. |
分子量 | 217.64 |
分子式 | C7H14ClF2NO2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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