Nitrofural

Name: Nitrofural
Brand: TargetMol
SKU: T9449
Price: 149 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.9%

货号 T9449Cas号 112574-44-4

别名 [(E)-(5-nitrofuran-2-yl)methylideneamino, (E)-2-((5-硝基呋喃-2-基)亚甲基)肼甲酰胺

Nitrofural 是 20 世纪已在临床应用中确立的硝基呋喃。 Nitrofural 在临床上对广泛的革兰氏阳性和革兰氏阴性细菌（包括许多常见的泌尿道病原体菌株）仍然有效。

Nitrofural

一键复制产品信息

很棒

纯度: 99.9%

货号 T9449 别名 [(E)-(5-nitrofuran-2-yl)methylideneamino, (E)-2-((5-硝基呋喃-2-基)亚甲基)肼甲酰胺Cas号 112574-44-4

规格	价格	库存
25 mg	¥ 149	现货
50 mg	¥ 163	现货
1 mL x 10 mM (in DMSO)	¥ 199	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Nitrofural AI Summary

Nitrofural demonstrates an extensive range of bioactivities across multiple biological targets and pathogens. It exhibits mutagenic activity in an Ames test, with a notable logP value of 0.23 indicating moderate lipophilicity. The compound has shown potent antimicrobial effects with a minimum inhibitory concentration (MIC) of 0.25 µg/mL against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. It also demonstrates significant inhibition against Trypanosoma brucei at varying micromolar concentrations, achieving 100% inhibition at concentrations as low as 1.5 µM. Furthermore, Nitrofural displays wound healing capabilities in rat models and cytotoxicity against cancer cells. It has demonstrated notable efficacy in radiosensitization and differential cytotoxicity under hypoxic conditions. In antiviral assays, it shows modest activity against SARS-CoV-2, including moderate protease inhibition and reduced virus-induced cytotoxicity. Additionally, the compound inhibits recombinant human SARM1 TIR domain and has variable inhibition effects on human HDAC6 enzyme activity. These diverse activities highlight Nitrofural as a multipotent agent with broad-spectrum antimicrobial, cytotoxic, and wound healing properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nitrofural is the nitrofurans that have become established in clinical use in the 20th century. Nitrofural has remained clinically useful against a wide spectrum of gram-positive and gram-negative bacteria, including many strains of common urinary tract pathogens.
别名	[(E)-(5-nitrofuran-2-yl)methylideneamino, (E)-2-((5-硝基呋喃-2-基)亚甲基)肼甲酰胺

化学信息

分子量	198.14
分子式	C₆H₆N₄O₄
CAS No.	112574-44-4
Smiles	N(=O)(=O)C=1OC(/C=N/NC(N)=O)=CC1
密度	1.70 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (252.35 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0469 mL	25.2347 mL	50.4694 mL	252.3468 mL
5 mM	1.0094 mL	5.0469 mL	10.0939 mL	50.4694 mL
10 mM	0.5047 mL	2.5235 mL	5.0469 mL	25.2347 mL
20 mM	0.2523 mL	1.2617 mL	2.5235 mL	12.6173 mL
50 mM	0.1009 mL	0.5047 mL	1.0094 mL	5.0469 mL
100 mM	0.0505 mL	0.2523 mL	0.5047 mL	2.5235 mL