MM 419447

Name: MM 419447
Brand: TargetMol
SKU: T38482
Rating: 4.5 (1 reviews)

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产品编号 T38482Cas号 1092457-78-7

MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.

MM 419447

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产品编号 T38482Cas号 1092457-78-7

MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.

规格	价格	库存	数量
25 mg	¥ 8,720	待询

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产品介绍

生物活性

产品描述	MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
体外活性	MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].
体内活性	MM 419447 (10 mg/kg; p.o.) treatment shows the C max , AUC 0-6 and t 1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]Animal Model: Female Sprague-Dawley rats[1]Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The C max , AUC 0-6 and T max were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.

化学信息

分子量	1363.55
分子式	C₅₀H₇₀N₁₄O₁₉S₆
CAS No.	1092457-78-7
密度	1.60 g/cm3 (Predicted)
Sequence Short	CCEYCCNPACTGC (Disulfide bridge:Cys1-Cys6; Cys2-Cys10; Cys5-Cys13)