Name: MK-7762
Brand: TargetMol
SKU: T218125
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述	MK-7762 is an oxazolidinone compound with oral antitubercular properties. It acts by inhibiting MAO-B and the synthesis of mitochondrial proteins in mammals. In BALB/c mice models with acute and chronic tuberculosis infection, MK-7762 reduces bacterial load in the lungs, penetrates caseous necrotic lung lesions in C3HeB/FeJ mice, and maintains concentrations above the free MIC in those lesions. MK-7762 is applicable in tuberculosis research.
体外活性	MK-7762 (0.93 μM; 7 天) 能有效抑制 95% 的 Mycobacterium tuberculosis (Mtb) 生长。MK-7762 (72 h) 对 HepG2 细胞中的哺乳动物线粒体蛋白质合成有抑制作用，IC 50 为 98 μM。MK-7762 (18.1 μM；7 天) 可杀灭 99% 的 H37Rv 细胞。MK-7762 (10 μM) 能抑制 MAO-B，IC 50 为 6.9 μM。
体内活性	MK-7762（30-100 mg/kg；灌胃；每日1或2次；连续12天）可显著降低急性感染BALB/c小鼠的肺部细菌载量。MK-7762（30-200 mg/kg；灌胃；每日1次；持续1个月）可降低慢性感染BALB/c小鼠的肺部细菌载量。MK-7762（100 mg/kg；灌胃；每日1次，每周5天；持续2.5周）可穿透C3HeB/FeJ小鼠的干酪样坏死病灶，且病灶内药物浓度高于游离MIC。
别名	TBD09

化学信息

分子量	419.40
分子式	C₁₆H₁₉F₂N₃O₆S
CAS No.	2706576-88-5
Smiles	O=C1N(C[C@H](CNC(OC)=O)O1)C2=CC(F)=C(C(F)=C2)N3CCS(=O)(=O)CC3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

MK-7762