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Flutrimazole

Name: Flutrimazole
Brand: TargetMol
SKU: T61148
Price: 196 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.51%

货号 T61148Cas号 119006-77-8

别名 氟曲马唑

Flutrimazole是一种具有双重作用的咪唑类抗真菌化合物，展现出抗炎和抗真菌的属性。值得注意的是，flutrimazole的经皮渗透性有限，这使其在治疗伴有炎症的真菌感染的局部应用中特别有优势。

为众多的药物研发团队赋能，

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Flutrimazole

一键复制产品信息

很棒

纯度: 99.51%

货号 T61148 别名 氟曲马唑Cas号 119006-77-8

规格	价格	库存
1 mg	¥ 196	现货
5 mg	¥ 465	现货
10 mg	¥ 738	现货
25 mg	¥ 1,350	现货
50 mg	¥ 2,230	现货
100 mg	¥ 3,190	现货
200 mg	¥ 4,430	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.51%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

生物活性

产品描述	Flutrimazole is a dual-action imidazole antifungal compound, exhibiting both anti-inflammatory and antifungal properties. Notably, flutrimazole demonstrates limited transdermal penetration, making it particularly advantageous for topical applications in the treatment of fungal infections, especially those accompanied by inflammation.
别名	氟曲马唑

化学信息

分子量	346.37
分子式	C₂₂H₁₆F₂N₂
CAS No.	119006-77-8
Smiles	Fc1ccc(cc1)C(c1ccccc1)(c1ccccc1F)n1ccnc1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 90 mg/mL (259.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.53 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8871 mL	14.4354 mL	28.8709 mL	144.3543 mL
5 mM	0.5774 mL	2.8871 mL	5.7742 mL	28.8709 mL
10 mM	0.2887 mL	1.4435 mL	2.8871 mL	14.4354 mL
20 mM	0.1444 mL	0.7218 mL	1.4435 mL	7.2177 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	2.8871 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4435 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Flutrimazole exhibits a range of bioactivities and pharmacological effects. It acts as an antagonist at human GTS-tagged FXR with an IC50 of 13,800 nM, inhibiting this receptor by 66.7% at 15 µM after 20 minutes according to TR-FRET assays. Additionally, it functions as an agonist at PXR in human HepG2 cells, inducing CYP3A4 transactivation with an EC50 of 6,100 nM and achieving maximum activation of 120.4% at 40 µM after 16 hours via luciferase reporter gene assay. In antiviral studies, Flutrimazole demonstrates activity against SARS-CoV-2. It inhibits the cytotoxicity of Caco-2 cells at 10 µM concentration after 48 hours, showing an inhibition of -0.2%. It also inhibits SARS-CoV-2 3CL-Pro protease by 8.479% at a concentration of 20 µM in a FRET peptide substrate assay and reduces SARS-CoV-2-induced cytotoxicity in VERO-6 cells by -0.09% at 10 µM after 48 hours. The compound also exhibits inhibitory activity against human HDAC6, with inhibition percentages of -9.89% and -3.26% in enzymatic assays utilizing commercial and custom peptide substrates, respectively. Moreover, Flutrimazole binds to various receptors, including human OPRK1, human ADORA3, human TBXA2R, human NR1I2, human MLNR, and human CCKBR, with AC50 values ranging from 560.0 nM to 29,999.9 nM. It shows agonist activity at human NR1I2 and human MLNR and acts antagonistically at rat Ar. In contrast, it displays low inhibitory effects or binding affinities toward targets such as KCNH2, Cacna1c, and ADRB1, with AC50 values exceeding 30,000.0 nM..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

Antifungal

Flutrimazole

Flutrimazole

Flutrimazole 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词