购物车

您的购物车当前为空

Flutrimazole

Name: Flutrimazole
Brand: TargetMol
SKU: T61148
Price: 196 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氟曲马唑

货号 T61148Cas号 119006-77-8 一键复制产品信息纯度: 99.51%

很棒

Flutrimazole是一种具有双重作用的咪唑类抗真菌化合物，展现出抗炎和抗真菌的属性。值得注意的是，flutrimazole的经皮渗透性有限，这使其在治疗伴有炎症的真菌感染的局部应用中特别有优势。

Flutrimazole

一键复制产品信息

很棒

纯度: 99.51%

货号 T61148Cas号 119006-77-8

别名 氟曲马唑

规格	价格	库存
1 mg	¥ 196	现货
5 mg	¥ 465	现货
10 mg	¥ 738	现货
25 mg	¥ 1,350	现货
50 mg	¥ 2,230	现货
100 mg	¥ 3,190	现货
200 mg	¥ 4,430	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.51%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Flutrimazole AI Summary

Flutrimazole exhibits a range of bioactivities and pharmacological effects. It acts as an antagonist at human GTS-tagged FXR with an IC50 of 13,800 nM, inhibiting this receptor by 66.7% at 15 µM after 20 minutes according to TR-FRET assays. Additionally, it functions as an agonist at PXR in human HepG2 cells, inducing CYP3A4 transactivation with an EC50 of 6,100 nM and achieving maximum activation of 120.4% at 40 µM after 16 hours via luciferase reporter gene assay. In antiviral studies, Flutrimazole demonstrates activity against SARS-CoV-2. It inhibits the cytotoxicity of Caco-2 cells at 10 µM concentration after 48 hours, showing an inhibition of -0.2%. It also inhibits SARS-CoV-2 3CL-Pro protease by 8.479% at a concentration of 20 µM in a FRET peptide substrate assay and reduces SARS-CoV-2-induced cytotoxicity in VERO-6 cells by -0.09% at 10 µM after 48 hours. The compound also exhibits inhibitory activity against human HDAC6, with inhibition percentages of -9.89% and -3.26% in enzymatic assays utilizing commercial and custom peptide substrates, respectively. Moreover, Flutrimazole binds to various receptors, including human OPRK1, human ADORA3, human TBXA2R, human NR1I2, human MLNR, and human CCKBR, with AC50 values ranging from 560.0 nM to 29,999.9 nM. It shows agonist activity at human NR1I2 and human MLNR and acts antagonistically at rat Ar. In contrast, it displays low inhibitory effects or binding affinities toward targets such as KCNH2, Cacna1c, and ADRB1, with AC50 values exceeding 30,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Flutrimazole is a dual-action imidazole antifungal compound, exhibiting both anti-inflammatory and antifungal properties. Notably, flutrimazole demonstrates limited transdermal penetration, making it particularly advantageous for topical applications in the treatment of fungal infections, especially those accompanied by inflammation.
别名	氟曲马唑

化学信息

分子量	346.37
分子式	C₂₂H₁₆F₂N₂
CAS No.	119006-77-8
Smiles	Fc1ccc(cc1)C(c1ccccc1)(c1ccccc1F)n1ccnc1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 90 mg/mL (259.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.53 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8871 mL	14.4354 mL	28.8709 mL	144.3543 mL
5 mM	0.5774 mL	2.8871 mL	5.7742 mL	28.8709 mL
10 mM	0.2887 mL	1.4435 mL	2.8871 mL	14.4354 mL
20 mM	0.1444 mL	0.7218 mL	1.4435 mL	7.2177 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	2.8871 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4435 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。