Euquinine

Name: Euquinine
Brand: TargetMol
SKU: T0519
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.83%

货号 T0519Cas号 83-75-0

别名 无味奎宁, Quinine ethylcarbonate

Euquinine (Quinine ethylcarbonate) 通常用作退热药、抗疟药和补品。

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Euquinine

一键复制产品信息

很棒

纯度: 99.83%

货号 T0519 别名 无味奎宁, Quinine ethylcarbonateCas号 83-75-0

Euquinine (Quinine ethylcarbonate) 通常用作退热药、抗疟药和补品。

规格	价格	库存
5 mg	¥ 216	现货
10 mg	¥ 389	现货
25 mg	¥ 506	现货
100 mg	¥ 704	现货
200 mg	¥ 1,267	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA HNMR LCMS 产品操作手册

产品介绍

Euquinine AI Summary

Euquinine inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells at 10 μM, with inhibition rates of 58.74% and 64.19%, respectively. It demonstrates bioactivity as an inhibitor against Marburg Virus with a potency of 19952.6 nM and exhibits gametocytocidal activity with a potency of 15848.9 nM. The compound shows some level of activity in inhibiting the cell viability of Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.6435. Additionally, it averts SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 42.85% at 10 μM after 48 hours. Although it displays antiviral activity against the SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells and Vero cells with hit scores of 0.1872 and 0.1489, respectively, these scores are below the typical threshold for a hit. It also inhibits SARS-CoV-2 3CL-Pro protease activity by 5.07% at 20 μM. However, it only minimally affects SARS-CoV-2-induced cytotoxicity in VERO-6 cells with an inhibition rate of -0.01% after 48 hours. In human HDAC6 assays, it shows a 14.49% inhibition rate with a commercial peptide substrate but a decrease in inhibition with a custom peptide substrate, exhibiting a rate of -0.15%..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Euquinine (Quinine ethylcarbonate) generally is served as the febrifuge, antimalarial, and tonic.
别名	无味奎宁, Quinine ethylcarbonate

化学信息

分子量	396.48
分子式	C₂₃H₂₈N₂O₄
CAS No.	83-75-0
Smiles	[C@H](OC(OCC)=O)([C@]1([N@@]2C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(C=CC(OC)=C4)N=CC3
密度	1.21g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (113.5 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5222 mL	12.6110 mL	25.2220 mL	126.1098 mL
5 mM	0.5044 mL	2.5222 mL	5.0444 mL	25.2220 mL
10 mM	0.2522 mL	1.2611 mL	2.5222 mL	12.6110 mL
20 mM	0.1261 mL	0.6305 mL	1.2611 mL	6.3055 mL
50 mM	0.0504 mL	0.2522 mL	0.5044 mL	2.5222 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2611 mL