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DENV-IN-15 是一种 sulfonyl anthranilic acid derivative,也是一种 pan-serotype 抗 dengue virus (DENV) inhibitor,具有广谱抗 RNA virus 活性;其在 Huh-7 细胞中抑制 DENV-2 的 EC50 为 0.7 μM。DENV-IN-15 可选择性调控编码 translation-related proteins 且含 5'端 oligopyrimidine motif 的 mRNA 翻译,降低特定 ribosomal proteins 的表达并抑制病毒复制,同时具有 improved membrane permeability、human plasma stability 和 human liver microsomal metabolic stability,可用于 dengue virus infection 相关研究。
DENV-IN-15 是一种 sulfonyl anthranilic acid derivative,也是一种 pan-serotype 抗 dengue virus (DENV) inhibitor,具有广谱抗 RNA virus 活性;其在 Huh-7 细胞中抑制 DENV-2 的 EC50 为 0.7 μM。DENV-IN-15 可选择性调控编码 translation-related proteins 且含 5'端 oligopyrimidine motif 的 mRNA 翻译,降低特定 ribosomal proteins 的表达并抑制病毒复制,同时具有 improved membrane permeability、human plasma stability 和 human liver microsomal metabolic stability,可用于 dengue virus infection 相关研究。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 10 mg | 待询 | 待询 | |
| 50 mg | 待询 | 待询 |
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| 产品描述 | DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum RNA virus activity. It has an EC50 of 0.7 μM against DENV-2 in Huh-7 cells. DENV-IN-15 selectively regulates the translation process of mRNA encoding translation-related proteins with a 5' oligopyrimidine motif and reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. Additionally, DENV-IN-15 enhances membrane permeability, human plasma stability, and human liver microsomal metabolic stability. It is useful for research related to dengue virus infection. |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 |
对于不同动物的给药剂量换算,您也可以参考 更多