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Corrector C4

Name: Corrector C4
Brand: TargetMol
SKU: T31014
Price: 1300 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: Corrector C-4, Corrector C 4, Corr-4a, Corr4a, Corr 4a

货号 T31014Cas号 421580-53-2 一键复制产品信息纯度: 99.98%

很棒

Corrector C4 是一种常用于研究囊性纤维化突变体的校正子，通过减轻CFTR跨膜结构域突变体与蛋白稳态的相互作用来发挥作用。

Corrector C4

一键复制产品信息

很棒

纯度: 99.98%

货号 T31014Cas号 421580-53-2

别名 Corrector C-4, Corrector C 4, Corr-4a, Corr4a, Corr 4a

Corrector C4 是一种常用于研究囊性纤维化突变体的校正子，通过减轻CFTR跨膜结构域突变体与蛋白稳态的相互作用来发挥作用。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 1,300	现货
5 mg	¥ 3,250	现货
10 mg	¥ 4,750	现货
25 mg	¥ 7,480	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,600	现货
500 mg	¥ 27,300	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。

如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.98%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR 产品操作手册

产品介绍

Corrector C4 AI Summary

Corrector C4 exhibits corrector activity on the human CFTR deltaF508 mutant expressed in FRT cells, evidenced by increases in iodide influx and YFP-based fluorescence analysis, with an EC50 value ranging from 1096.48 nM to 2300.0 nM. The compound shows a Vmax value of 122.0 microM/s and a Kd value of 900.0 nM, along with an IC50 value of 6000.0 nM for iodide influx assessed by fluorescence assay. Beyond its role as a CFTR corrector, Corrector C4 demonstrates a broad spectrum of bioactivities including modulation of Lamin A splicing, SMN2 splice variant expression, and inhibition of tau fibril formation, AMP beta-lactamase, ALDH1A1, Jumonji Domain Containing 2E, Cruzain, Menin-MLL interaction, HPGD, Eya2, Histone Lysine Methyltransferase G9a, BAZ2B, and TCP-1 ring complex. It exhibits anti-tumor efficacy in certain human colon tumor cells and shows potential against malarial parasite plastids with potencies ranging from 707.9 nM to 199526.2 nM across different assays. Its physicochemical properties include a Log P value of 5.96, a solubility of 20.0 nM, an apparent permeability of 8.1 x 10^-6 cm/s, and membrane retention of 37.9%. The compound maintains metabolic stability, with approximately 55% remaining after 1-hour incubation with CYP3A4 and a human plasma half-life of 86.6 hours. Additionally, it has a binding affinity to human serum albumin with a dissociation constant of 11680.0 nM and a Bmax of 88.82%. Corrector C4 is soluble in 50 mM ammonium acetate buffer at 250 μM and demonstrates efficacy in correcting defective trafficking of the CFTR protein with demonstrated activities in various cell lines upon pre-incubation and forskolin/genistein stimulation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.
别名	Corrector C-4, Corrector C 4, Corr-4a, Corr4a, Corr 4a

化学信息

分子量	456.97
分子式	C₂₁H₁₇ClN₄O₂S₂
CAS No.	421580-53-2
Smiles	CC1=C(C=2N=C(NC3=C(OC)C=CC(Cl)=C3)SC2)SC(NC(=O)C4=CC=CC=C4)=N1
密度	1.440 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 60 mg/mL (131.3 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1883 mL	10.9416 mL	21.8833 mL	109.4164 mL
5 mM	0.4377 mL	2.1883 mL	4.3767 mL	21.8833 mL
10 mM	0.2188 mL	1.0942 mL	2.1883 mL	10.9416 mL
20 mM	0.1094 mL	0.5471 mL	1.0942 mL	5.4708 mL
50 mM	0.0438 mL	0.2188 mL	0.4377 mL	2.1883 mL
100 mM	0.0219 mL	0.1094 mL	0.2188 mL	1.0942 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。