Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage[1].
产品描述 | Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage[1]. |
体外活性 | Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations[2]. |
体内活性 | The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/-) 57:43[3]. |
分子量 | 268.34 |
分子式 | C10H16N6OS |
CAS No. | 54237-72-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (310.54 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7266 mL | 18.6331 mL | 37.2662 mL | 93.1654 mL |
5 mM | 0.7453 mL | 3.7266 mL | 7.4532 mL | 18.6331 mL | |
10 mM | 0.3727 mL | 1.8633 mL | 3.7266 mL | 9.3165 mL | |
20 mM | 0.1863 mL | 0.9317 mL | 1.8633 mL | 4.6583 mL | |
50 mM | 0.0745 mL | 0.3727 mL | 0.7453 mL | 1.8633 mL | |
100 mM | 0.0373 mL | 0.1863 mL | 0.3727 mL | 0.9317 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cimetidine sulfoxide 54237-72-8 Inhibitor inhibitor inhibit