Name: Brolucizumab
Brand: TargetMol
SKU: T80593
Price: 8130 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 8,130

现货

5 mg

¥ 16,200

现货

10 mg

¥ 21,900

现货

25 mg

¥ 32,600

现货

50 mg

¥ 43,800

现货

生物活性

产品描述	Brolucizumab (DLX1008) is a single-chain variable fragment (scFv) anti-VEGF-A antibody exhibiting an exceptionally low picomolar binding affinity (K D = 1.05 pM). through its potent blockade of vascular endothelial growth factor A (VEGF-A), Brolucizumab effectively reduces pathological neovascularization and vascular leakage within the macula and is under investigation for the treatment of neovascular (wet) age-related macular degeneration (AMD).
体外活性	Brolucizumab (2683 nM) 处理VEGF-A112 诱导的 U87MG 人神经胶质瘤细胞，能够抑制 VEGFR1 磷酸化和 ZHE-483-2 GMEC 中的 VEGFR2 磷酸化。[1]
体内活性	Brolucizumab (15 mg/kg，静脉注射，一周五天) 处理mSLK-KSHV 异种移植，观察体内肿瘤生长情况。结果：Brolucizumab 可减缓 mSLK-KSHV 异种移植肿瘤的生长。[2]
别名	布洛赛珠单抗, RTH258, ESBA 1008, DLX1008
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

抗体信息

同型	scFv-kappa-heavy

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	~150 kDa
CAS No.	1531589-13-5

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Brolucizumab