Name: ATN-658
Brand: TargetMol
SKU: T9901A-1238
Rating: 4.5 (1 reviews)

生物活性

产品描述	ATN-658 is a humanized monoclonal antibody target the Domain 3 region of the urokinase-type plasminogen activator receptor, inhibition of cellular migration and invasion by disrupting the functional interaction between the receptor and various integrin signaling partners within designated preclinical oncology models.
体外活性	在 PC-3 前列腺癌细胞实验中，ATN-658 导致细胞运动能力出现显著且呈剂量依赖性的下降 [1]。
体内活性	在 PC-3 骨内异种移植模型中，通过全身给药方式给予 ATN-658，实验结果显示其显著降低了肿瘤体积并减轻了骨部损伤 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q03405
靶点	PLAUR/uPAR/CD87

储存&溶解度

存储

ATN-658