规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述

Antibiofilm agent-5 (compound 6c) is a multitarget antibacterial agent with potent antibiofilm activity. It induces metabolic dysfunction by inactivating lactate dehydrogenase, promoting the accumulation of reactive oxygen species, which subsequently reduces reduced glutathione and leads to bacterial oxidative damage. Antibiofilm agent-5 is applicable for studying recalcitrant biofilm-enhanced bacterial infections.

体外活性

Antibiofilm agent-5（compound 6c）对鲍曼不动杆菌和大肠杆菌表现出比norfloxacin更强的抑制活性，MIC值为0.0066 mmol/L。该化合物能够插入DNA，形成6c-DNA超分子复合物，从而引发细胞死亡。Antibiofilm agent-5对人红细胞的溶血作用不明显，对人正常肝细胞(LO2)和肺上皮细胞(BEAS-2B)的细胞毒性较低，且没有跨越血脑屏障的风险。