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顶部生物活性储存和溶解信息计算器

Anti-VEGFR2/KDR Antibody-APC (6M522)

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Anti-VEGFR2/KDR Antibody-APC (6M522)
产品编号 TMAY-03509A
别名 VEGFR2, VEGFR, kinase insert domain receptor, Flk-1, FLK1, CD309

Anti-VEGFR2/KDR Antibody-APC (6M522) 是一种 APC-conjugated Rabbit 抗体，靶向 VEGFR2/KDR。Anti-VEGFR2/KDR Antibody-APC (6M522) 可用于 FCM。

Anti-VEGFR2/KDR Antibody-APC (6M522)
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Anti-VEGFR2/KDR Antibody-APC (6M522)

Rating icon 还可以
Anti-VEGFR2/KDR Antibody-APC (6M522)
产品编号 TMAY-03509A 别名 VEGFR2, VEGFR, kinase insert domain receptor, Flk-1, FLK1, CD309

Anti-VEGFR2/KDR Antibody-APC (6M522) 是一种 APC-conjugated Rabbit 抗体，靶向 VEGFR2/KDR。Anti-VEGFR2/KDR Antibody-APC (6M522) 可用于 FCM。

规格价格库存数量
25 T
¥ 890
5日内发货
100 T
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-VEGFR2/KDR Antibody-APC (6M522) is a APC-conjugated Rabbit antibody targeting VEGFR2/KDR. Anti-VEGFR2/KDR Antibody-APC (6M522) can be used in FCM.
别名VEGFR2, VEGFR, kinase insert domain receptor, Flk-1, FLK1, CD309
Ig Type
Rabbit IgG
克隆号
6M522
交叉反应
Mouse
验证活性
1. Flow cytometric analysis of Mouse ENG(CD105) expression on bEnd.3 cells. Cells were stained with APC-conjugated anti-Mouse ENG(CD105). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
2. Flow cytometric analysis of Mouse KDR(CD309) expression on bEnd.3 cells. Cells were stained with APC-conjugated anti-Mouse KDR(CD309). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
5 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse VEGFR2 / Flk-1 / CD309 / KDR (rM VEGFR2 / Flk-1 / CD309 / KDR; TMPY-02736; P35918-1; Met1-Glu762) and conjugated with APC under optimum conditions, the unreacted APC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.09% sodium azide
研究背景VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling are critical to endothelial cell survival, maintenance of the vasculature and alveolar structure, and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
APC
其他可选修饰符
Unconjugated/PE
可提供抗体种类
3
抗原信息
免疫原
Recombinant Protein: Mouse VEGFR2 / Flk-1 / CD309 / KDR Protein (TMPY-02736)
抗原种属
Mouse
研究领域
Cancer Drug Targets, Hemangioblast Markers, Receptor Tyrosine Kinases (RTKs)
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
运输方式Shipping with blue ice.

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关键词

VEGFR-2VEGFR 2FLK-1FLK 1CD-309CD 309

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