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Anti-VEGFR2/KDR Antibody (5U735)
还可以产品编号 TMAY-00062
Anti-VEGFR2/KDR Antibody (5U735) 是一种 Mouse 抗体，靶向 VEGFR2/KDR。Anti-VEGFR2/KDR Antibody (5U735) 可用于 ELISA,FCM。
Anti-VEGFR2/KDR Antibody (5U735)
Anti-VEGFR2/KDR Antibody (5U735)
还可以产品编号 TMAY-00062
Anti-VEGFR2/KDR Antibody (5U735) 是一种 Mouse 抗体，靶向 VEGFR2/KDR。Anti-VEGFR2/KDR Antibody (5U735) 可用于 ELISA,FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-VEGFR2/KDR Antibody (5U735) is a Mouse antibody targeting VEGFR2/KDR. Anti-VEGFR2/KDR Antibody (5U735) can be used in ELISA,FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5U735 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human VEGFR2(CD309) expression on HUVEC cells. Cells were stained with purified anti-Human VEGFR2(CD309), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | ELISA,FCM |
| 推荐剂量 | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VEGFR2 / KDR / Flk-1 / CD309 (rh VEGFR2 / KDR / Flk-1 / CD309; TMPY-02361; NP_002244.1; Met1-Glu764). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling are critical to endothelial cell survival, maintenance of the vasculature and alveolar structure, and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human VEGFR2 / KDR / Flk-1 / CD309 Protein (TMPY-02361) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Hemangioblast Markers, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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