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Anti-VEGFR2/KDR Antibody (3T987)
还可以产品编号 TMAH-00664
别名 VEGFR-21, VEGFR2, VEGFR, Ly73, KRD1, KDR, FLK1, CD309
Anti-VEGFR2/KDR Antibody (3T987) 是一种抗体，靶向 VEGFR2/KDR。Anti-VEGFR2/KDR Antibody (3T987) 可用于 ELISA, IHC。
Anti-VEGFR2/KDR Antibody (3T987)
Anti-VEGFR2/KDR Antibody (3T987)
还可以产品编号 TMAH-00664 别名 VEGFR-21, VEGFR2, VEGFR, Ly73, KRD1, KDR, FLK1, CD309
Anti-VEGFR2/KDR Antibody (3T987) 是一种抗体，靶向 VEGFR2/KDR。Anti-VEGFR2/KDR Antibody (3T987) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-VEGFR2/KDR Antibody (3T987) is an antibody targeting VEGFR2/KDR. Anti-VEGFR2/KDR Antibody (3T987) can be used in ELISA, IHC. |
| 别名 | VEGFR-21, VEGFR2, VEGFR, Ly73, KRD1, KDR, FLK1, CD309 |
| Ig Type | hIgG1 |
| 克隆号 | 3T987 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00664 diluted at 1:200 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell junction. Endoplasmic reticulum. Cell membrane.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human KDR Protein |
| 抗原种属 | Human |
| 基因ID | 3791 |
| Uniprot ID | |
| 研究领域 | Cancer, Cardiovascular, Metabolism, Microbiology, Signal transduction, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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