Anti-TNBC agent-15 is a platinum (IV) complex with activity against triple-negative breast cancer. It inhibits cancer cell viability and reverses resistance to Cisplatin in these cancer cells, increasing intracellular uptake. By inducing DNA damage, accumulating intracellular ROS, and activating the mitochondrial pathway, it effectively triggers apoptosis. Anti-TNBC agent-15 also enhances lipid peroxidation and disrupts the cystine/glutamate transporter-glutathione peroxidase signaling axis, inducing ferroptosis. In triple-negative breast cancer/Cisplatin xenograft models, it significantly suppresses tumor growth. Anti-TNBC agent-15 is applicable for research on triple-negative breast cancer.