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Anti-SLAMF7 Antibody (7U446)
还可以产品编号 TMAY-02004
Anti-SLAMF7 Antibody (7U446) 是一种 Rabbit 抗体，靶向 SLAMF7。Anti-SLAMF7 Antibody (7U446) 可用于 ELISA。
Anti-SLAMF7 Antibody (7U446)
Anti-SLAMF7 Antibody (7U446)
还可以产品编号 TMAY-02004
Anti-SLAMF7 Antibody (7U446) 是一种 Rabbit 抗体，靶向 SLAMF7。Anti-SLAMF7 Antibody (7U446) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-SLAMF7 Antibody (7U446) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (7U446) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7U446 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CRACC / SLAM7 / CD319 (rh CRACC / SLAM7 / CD319; TMPY-01483; NP_067004.3; Met1-Met226). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CRACC / SLAM7 / CD319 Protein (TMPY-01483) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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