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顶部生物活性储存和溶解信息计算器

Anti-SLAMF7 Antibody (7U446)

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产品编号 TMAY-02004

别名 SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A

Anti-SLAMF7 Antibody (7U446) 是一种 Rabbit 抗体，靶向 SLAMF7。Anti-SLAMF7 Antibody (7U446) 可用于 ELISA。

Anti-SLAMF7 Antibody (7U446)

Anti-SLAMF7 Antibody (7U446)

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产品编号 TMAY-02004 别名 SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A

Anti-SLAMF7 Antibody (7U446) 是一种 Rabbit 抗体，靶向 SLAMF7。Anti-SLAMF7 Antibody (7U446) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 2,284
5日内发货
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产品介绍

生物活性
产品描述
Anti-SLAMF7 Antibody (7U446) is a Rabbit antibody targeting SLAMF7. Anti-SLAMF7 Antibody (7U446) can be used in ELISA.
别名SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A
Ig Type
Rabbit IgG
克隆号
7U446
交叉反应
Human
特异性
Human SLAMF7/CRACC/CS1
应用ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human CRACC / SLAM7 / CD319 (rh CRACC / SLAM7 / CD319; TMPY-01483; NP_067004.3; Met1-Met226).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human CRACC / SLAM7 / CD319 Protein (TMPY-01483)
抗原种属
Human
研究领域
Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

SLAM-7SLAM 7CS-1CS 1CD-319CD 319

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