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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-JAK2 Antibody (1H255)

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货号 TMAH-00655

Anti-JAK2 Antibody (1H255) 是一种抗体，靶向 JAK2。Anti-JAK2 Antibody (1H255) 可用于 ELISA,IF。

Anti-JAK2 Antibody (1H255)

Anti-JAK2 Antibody (1H255)

一键复制产品信息
Rating icon 还可以
货号 TMAH-00655

Anti-JAK2 Antibody (1H255) 是一种抗体，靶向 JAK2。Anti-JAK2 Antibody (1H255) 可用于 ELISA,IF。

规格价格库存数量
50 μL
¥ 1,315
5日内发货
100 μL
¥ 2,195
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
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产品介绍

生物活性
产品描述
Anti-JAK2 Antibody (1H255) is an antibody targeting JAK2. Anti-JAK2 Antibody (1H255) can be used in ELISA,IF.
Ig Type
Rabbit IgG
克隆号
1H255
反应种属
Human
验证活性
Immunofluorescence staining of Hela Cells with TMAH-00655 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
应用ELISAIF
推荐剂量
IF:1:20-1:200.
抗体种类
Monoclonal
亚细胞定位Endomembrane system; Peripheral membrane protein. Cytoplasm. Nucleus.
组织特异性Ubiquitously expressed throughout most tissues.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human JAK2
抗原种属
Human
基因名称
JAK2
基因ID
3717
Uniprot ID
O60674
研究领域
Epigenetics and Nuclear Signaling, Cancer, Cell biology, Signal transduction
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

Tyrosine-protein kinase JAK2Janus kinase 2 (JAK-2)JAK-2JAK2JAK 2
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