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Anti-FLT3 Antibody (2N391)
还可以产品编号 TMAY-00840
Anti-FLT3 Antibody (2N391) 是一种 Mouse 抗体，靶向 FLT3。Anti-FLT3 Antibody (2N391) 可用于 FCM。
Anti-FLT3 Antibody (2N391)
Anti-FLT3 Antibody (2N391)
还可以产品编号 TMAY-00840
Anti-FLT3 Antibody (2N391) 是一种 Mouse 抗体，靶向 FLT3。Anti-FLT3 Antibody (2N391) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-FLT3 Antibody (2N391) is a Mouse antibody targeting FLT3. Anti-FLT3 Antibody (2N391) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2N391 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human FLT3(CD135) expression on Human blood monocytes. Cells were stained with purified anti-Human FLT3(CD135), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable monocytes. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FLT-3 / CD135 / FLK-2 (rh FLT-3 / CD135 / FLK-2; TMPY-01247; P36888-1; Met1-Asn541,T227M). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD135, also known as FLT-3, FLK-2, is a member of the CD system. CD135 is an important cell surface marker recognized by specific sets of antibodies to identify the types of hematopoietic (blood) progenitors in the bone marrow and it function to differentiate hematopoietic stem cells, which are CD135 negative, from multipotent progenitors, which are CD135 positive. CD135 is a receptor tyrosine kinase typeⅢ for the cytokine Flt3 ligand and activat signaling through second messengers by binding to Flt3. Signaling through CD135 is important for lymphocyte development. The encoding gene CD135 is a proto-oncogene to which mutations happened will lead to cancer such as leukemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human FLT-3 / CD135 / FLK-2 protein (TMPY-01247) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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