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Anti-CD73 Antibody (4N525)
还可以产品编号 TMAY-01318
Anti-CD73 Antibody (4N525) 是一种 Rabbit 抗体，靶向 CD73。Anti-CD73 Antibody (4N525) 可用于 WB,IHC-P。
Anti-CD73 Antibody (4N525)
Anti-CD73 Antibody (4N525)
还可以产品编号 TMAY-01318
Anti-CD73 Antibody (4N525) 是一种 Rabbit 抗体，靶向 CD73。Anti-CD73 Antibody (4N525) 可用于 WB,IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD73 Antibody (4N525) is a Rabbit antibody targeting CD73. Anti-CD73 Antibody (4N525) can be used in WB,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4N525 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human NT5E in human spleen with rabbit monoclonal antibody (1:5000, formalin-fixed paraffin embedded sections). 2. Anti-NT5E rabbit monoclonal antibody at 1:500 dilution. -Lane A: NCI-H1299 Whole Cell Lysate. -Lane B: HepG2 Whole Cell Lysate. -Lane C: Hela Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:63 kDa. -Observed band size:70 kDa(We are unsure as to the identity of these extra bands.) |
| 应用 | WB,IHC-P |
| 推荐剂量 | WB: 1:500-1:2000; IHC-P: 1:2500-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD73 / NT5E (rh CD73 / NT5E; TMPY-01851; NP_002517.1; Met1-Lys547). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | 5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes. CD73 catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. CD73 serves as a costimulatory molecule in activating T cells. CD73 generated adenosine functions in cell signaling in many physiologic systems, including intestinal epithelium, ischemic myocardium, and cholinergic synapses. CD73 might mediate lymphocyte-stromal cell interactions or condition the local microenvironment to facilitate lymphocyte development and/or function. In CD73-depleted cells, surface levels of the leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin increase. CD73 produces extracellular adenosine, which then acts on G protein-coupled purinergic receptors to induce cellular responses. CD73 has also been reported to regulate the expression of pro-inflammatory molecules in mouse endothelium. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD73 / NT5E Protein (TMPY-01851) |
| 抗原种属 | Human |
| 研究领域 | Phosphatases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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