AA76-lipid (Compound aa76) is a chemical compound characterized by an arginine terminus and a histidine structure. It is utilized in the preparation of pancreas-targeted lipid nanoparticles, known as AH-LNP. When AH-LNP assembles with proteins, its size increases, thereby enhancing Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, leading to improved pancreas-targeting capability. AA76-lipid is capable of selectively delivering mRNA to the pancreas and is applicable in pancreatic cancer research.