Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TD-198946 是一种高效的软骨形成剂,是一种噻吩并唑衍生物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 898 | 现货 | ||
2 mg | ¥ 1,250 | 现货 | ||
5 mg | ¥ 1,820 | 现货 | ||
10 mg | ¥ 2,880 | 现货 | ||
25 mg | ¥ 5,220 | 现货 | ||
50 mg | ¥ 6,910 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,960 | 现货 |
产品描述 | TD-198946, a potent chondrogenic agent, is a thienoindazole derivative. |
体外活性 | In cell and metatarsal organ cultures, TD-198946 markedly induces chondrogenic differentiation without promoting hypertrophy. In ATDC5 cells, TD-198946 induces stronger?Col2a1?promoter activity than insulin. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers?Acan?and?Col2a1 (maximum effects: 1-10 μM). |
体内活性 | TD-198946 can prevent and repair degeneration of the articular cartilage by administered directly into the joint space. TD-198946 regulates Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage. Cartilaginous cell-sheets are generated by culturing human mesenchymal stem cells and canine and mouse costal chondrocytes with TD-198946 on temperature-responsive dishes. |
动物实验 | For intra-articular injection, TD-198946 is dissolved at 100 nM in a solution of 45% 2-hydropropyl-b-cyclodextrin in saline.Mouse: Each of the prevention and repair models had two groups: (1) TD-198946-treated animals and (2) saline-treated animals. In all the mice tested the left knee joints underwent the operation and the right knee joints are sham-operated. Mice are re-anesthetized and given a 10 μL intra-articular injection of TD-198946 or saline immediately after surgery (prevention model) or 4 weeks following surgery (repair model) every 5 days for 8 or 4 weeks, respectively. |
别名 | TD198946, TD 198946 |
分子量 | 482.55 |
分子式 | C27H22N4O3S |
CAS No. | 364762-86-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (103.62 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0723 mL | 10.3616 mL | 20.7232 mL | 51.8081 mL |
5 mM | 0.4145 mL | 2.0723 mL | 4.1446 mL | 10.3616 mL | |
10 mM | 0.2072 mL | 1.0362 mL | 2.0723 mL | 5.1808 mL | |
20 mM | 0.1036 mL | 0.5181 mL | 1.0362 mL | 2.5904 mL | |
50 mM | 0.0414 mL | 0.2072 mL | 0.4145 mL | 1.0362 mL | |
100 mM | 0.0207 mL | 0.1036 mL | 0.2072 mL | 0.5181 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TD-198946 364762-86-7 Others inhibit TD198946 TD 198946 Inhibitor inhibitor