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Nystatin A3

产品编号 T6913 CAS 62997-67-5

别名: 制霉菌素 A3, 制霉菌素, Fungicidin, Nystatin

Nystatin A3 (Fungicidin) 是从Streptomyces noursei 中产生的一种多烯类抗真菌药，用作治疗口咽念珠菌病的外用剂。

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Nystatin A3, CAS 62997-67-5

规格	价格/CNY	货期
25 mg	￥ 432	待询
50 mg	￥ 640	待询
100 mg	￥ 1,152	待询
200 mg	￥ 2,074	待询
1 mL * 10 mM (in DMSO)	￥ 235	待询

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Nystatin A3 的其他形式现货产品:

Nystatin

其他形式的 Nystatin A3:

Nystatin
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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Nystatin A3 (Fungicidin) , which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
体外活性	Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six?Candida?species. [1] Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/ml) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [3H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment. [2] Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of?endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. [3]
体内活性	Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. [3] Liposomal?Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. [4]

别名	制霉菌素 A3, 制霉菌素, Fungicidin, Nystatin
分子量	1056.24
分子式	C53H85NO20
CAS No.	62997-67-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 16 mg/mL (15.1 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9468 mL	4.7338 mL	9.4675 mL	23.6689 mL
	5 mM	0.1894 mL	0.9468 mL	1.8935 mL	4.7338 mL
	10 mM	0.0947 mL	0.4734 mL	0.9468 mL	2.3669 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Ellepola AN, et al. Oral Microbiol Immunol. 1999 Dec;14(6):358-63. 2. Haas M, et al. Am J Physiol,1994, 266(5 Pt 1), C1440-1452. 3. Chen Y, et al. Blood,2011, 117(23), 6392-6403. 4. Wallace TL, et al. Antimicrob Agents Chemother,1997, 41(10), 2238-2243.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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