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Methyl-β-cyclodextrin

Methyl-β-cyclodextrin

产品编号 T4072   CAS 128446-36-6
别名: 甲基-β-环糊精, 甲基倍他环糊精, beta-Cyclodextrin methyl ethers, Methyl-beta-cyclodextrin

Methyl-β-cyclodextrin 是一种环庚糖,对非极性物质有增溶作用,可显著降低网格蛋白依赖性内吞作用。它广泛应用于疏水性药物的释放,也广泛用作降胆固醇剂。

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Methyl-β-cyclodextrin, CAS 128446-36-6
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产品目录号及名称: Methyl-β-cyclodextrin (T4072)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Methyl-β-cyclodextrin, a cyclic heptasaccharide, is an effective agent for the depletion of cholesterol from cells; also inhibits PEL cell growth with an IC50 of 3.33-4.23 mM.
靶点活性 PEL:3.33-4.23 mM.
体外活性 Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner. The IC50 is 3.33-4.23 mM in each cell line. Methyl-b-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents.
体内活性 Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. In a PEL xenograft mouse model, methyl-b-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-b-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of M-b-CyD treated mice. Methyl-b-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice.
激酶实验 PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined.
细胞实验 PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined[1].
别名 甲基-β-环糊精, 甲基倍他环糊精, beta-Cyclodextrin methyl ethers, Methyl-beta-cyclodextrin
分子量 1310
分子式 C54H94O35
CAS No. 128446-36-6

存储

 | Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

DMSO: 31 mg/mL

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Gotoh, K., Kariya, R., Alam, M., Matsuda, K., Hattori, S., & Maeda, Y. et al. (2014). The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochemical And Biophysical Research Communications, 455(3-4), 285-289. doi: 10.1016/j.bbrc.2014.11.006 2. Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9. 3. Li X, Tang H, Huang X, et al. Rigidity‐Dependent Placental Cells Uptake of Silk‐Based Microcapsules[J]. Macromolecular bioscience. 2019: 1900105. 4. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2019: 1-16.

文献引用

1. Lu J Y, Huang W T, Zhou K, et al. Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity. Small. 2021: 2104034. 2. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2020, 27(4): 1243-1258 3. Li X, Tang H, Huang X, et al. Rigidity‐Dependent Placental Cells Uptake of Silk‐Based Microcapsules. Macromolecular bioscience. 2019: 1900105. 4. Zeng L, Liu H, Liu Z, et al.Defected lipid rafts suppress cavin1-dependent IFN-α signaling endosome in paroxysmal nocturnal hemoglobinuria.International Immunopharmacology.2023, 115: 109468. 5. Wang T, Wang L, Li W, et al.Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway.Veterinary Research.2023, 54(1): 1-14.

相关化合物库

该产品包含在如下化合物库中:
经典已知活性库 NO PAINS 化合物库 大环化合物库 临床前化合物库 已知活性化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
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稀释计算器
配液计算器
分子量计算器
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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Methyl-β-cyclodextrin 128446-36-6 Others Inhibitor Methylβcyclodextrin 甲基-β-环糊精 甲基倍他环糊精 beta-Cyclodextrin methyl ethers Methyl β cyclodextrin inhibit Methyl-beta-cyclodextrin inhibitor

 

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