Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FAUC-365 是一种高度选择性的多巴胺D3受体拮抗剂,能够作用于 D3 受体(Ki:0.5 nM)、D4.4 受体(Ki:340 nM)、D2short 受体(Ki:2600 nM)和 D2Long 受体(Ki:3600 nM)。它可用于研究帕金森病、精神分裂症等疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 461 | 现货 | ||
5 mg | ¥ 1,160 | 现货 | ||
10 mg | ¥ 1,730 | 现货 | ||
25 mg | ¥ 3,390 | 现货 | ||
50 mg | ¥ 4,930 | 现货 | ||
100 mg | ¥ 7,160 | 现货 | ||
500 mg | ¥ 14,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,280 | 现货 |
产品描述 | FAUC-365 is a D3 dopamine receptor agonist. |
靶点活性 | 5-HT:0.50 nM(Ki) |
体外活性 | As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively [1]. |
别名 | FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide, FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide |
分子量 | 462.44 |
分子式 | C23H25Cl2N3OS |
CAS No. | 474432-66-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: insoluble
DMSO: 50 mg/mL (108.12 mM)
EtOH: insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1624 mL | 10.8122 mL | 21.6244 mL | 54.0611 mL |
5 mM | 0.4325 mL | 2.1624 mL | 4.3249 mL | 10.8122 mL | |
10 mM | 0.2162 mL | 1.0812 mL | 2.1624 mL | 5.4061 mL | |
20 mM | 0.1081 mL | 0.5406 mL | 1.0812 mL | 2.7031 mL | |
50 mM | 0.0432 mL | 0.2162 mL | 0.4325 mL | 1.0812 mL | |
100 mM | 0.0216 mL | 0.1081 mL | 0.2162 mL | 0.5406 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
FAUC-365 474432-66-1 GPCR/G Protein Neuroscience Dopamine Receptor inhibit Parkinson's disease FAUC365 D3 receptor Dopamine Inhibitor schizophrenia SPET FAUC 365 FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide Radioligand FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide inhibitor