Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂,IC50值分别为 10 和 2.1 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 221 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 798 | 现货 | ||
25 mg | ¥ 1,730 | 现货 | ||
50 mg | ¥ 2,890 | 现货 | ||
100 mg | ¥ 4,270 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 537 | 现货 |
产品描述 | CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM). |
靶点活性 | CaCC:10 μM, TMEM16A:2.1 μM |
体外活性 | Tannic acid (100 μM) and CaCCinh-A01 (30 μM) effectively inhibit CaCC current following ATP stimulation[1]. CaCCinh-A01 (0.1/1/10 μM) reduces Calcium-dependent chloride current (38±14, 66±10, and 91±1%). ATP-induced short-circuits currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively. |
细胞实验 | Each well of a 96-well plate is washed three times with PBS (200 μL/wash), leaving 50 μL of PBS. Test compounds (including CaCCinh-A01) (0.5 μL) are added to each well at 25 μM final concentration. After 10 min, 96-well plates are transferred to a plate reader for fluorescence assay. Each well is assayed individually for TMEM16A-mediated I- influx by recording fluorescence continuously (400 ms/point) for 2 s (baseline), then 50 μL of a 140 mM I-solution containing 200 μM ATP is added. |
分子量 | 347.43 |
分子式 | C18H21NO4S |
CAS No. | 407587-33-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (158.31 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8783 mL | 14.3914 mL | 28.7828 mL | 71.9569 mL |
5 mM | 0.5757 mL | 2.8783 mL | 5.7566 mL | 14.3914 mL | |
10 mM | 0.2878 mL | 1.4391 mL | 2.8783 mL | 7.1957 mL | |
20 mM | 0.1439 mL | 0.7196 mL | 1.4391 mL | 3.5978 mL | |
50 mM | 0.0576 mL | 0.2878 mL | 0.5757 mL | 1.4391 mL | |
100 mM | 0.0288 mL | 0.1439 mL | 0.2878 mL | 0.7196 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CaCCinh-A01 407587-33-1 Membrane transporter/Ion channel Chloride channel TMEM16A infarction inhibit Inhibitor neurological CaCCinh-A-01 cerebral artery occlusion CaCCinhA01 Cl? Channels Chloride Channel CaCCinh A01 deficit inhibitor