2-Aminofluorene

Name: 2-Aminofluorene
Brand: TargetMol
SKU: T21285
Rating: 4.5 (1 reviews)

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很棒

纯度: 99.9%

货号 T21285Cas号 153-78-6

别名 2-氨基芴, 2-Fluorenamine

2-Aminofluorene (2-Fluorenamine) 是一种生化物质。

2-Aminofluorene

一键复制产品信息

很棒

纯度: 99.9%

货号 T21285 别名 2-氨基芴, 2-FluorenamineCas号 153-78-6

2-Aminofluorene (2-Fluorenamine) 是一种生化物质。

规格	价格	库存	数量
500 mg	¥ 99	待询
1 mL x 10 mM (in DMSO)	¥ 99	现货

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产品介绍

2-Aminofluorene AI Summary

2-Aminofluorene is a bioactive molecule that functions as a competitive inhibitor for the [3H]benzo[a]pyrene-binding site of the polycyclic aromatic hydrocarbon binding protein (PBP) in mouse liver, with a calculated binding free energy (ΔGm) of 11.9. It exhibits moderate hydrophobicity with a LogP value of 3.14 and good solubility in water at 8780.0 µg/mL, making it readily available for biological processes in aqueous environments. In terms of bioactivity, 2-Aminofluorene shows significant activities across various assays, including: - Modulation of Lamin A splicing (potency: 199.5 nM). - Inhibition of Human Jumonji Domain Containing 2E (JMJD2E) (potency: 28183.8 nM). - Inhibition of ATPase activity of Tag (IC50: 4770.0 nM). - Modulation of miRNAs and activation of miR-21 (potency: 6561.4 nM). - Activation of Rab9 Promoter (potency: 3548.1 nM). - Enhancement of SMN2 splice variant expression (potency: 14125.4 nM). - Inhibition of Tau fibril formation (potency: 19952.6 nM and 22.4 nM in different assays). - Inhibition of Aldehyde Dehydrogenase 1 (ALDH1A1) (potency: 25118.9 nM). - Modulation of lipid storage in Drosophila S3 cells (potency: 7307.8 nM). - Inhibition of various tumor cell lines with GI50 values ranging from 19453.6 nM to 100000.0 nM. The compound shows enzymatic activities with human recombinant enzymes, including UGT1A3 (activity: 84.0 pmol/min/mg) and UGT1A4 (activity: 540.0 pmol/min/mg), suggesting roles in the metabolism and conjugation of xenobiotics and endogenous substances. Moreover, 2-Aminofluorene exhibits mutagenic activity in Salmonella typhimurium strains TA 98 and TA 100, showing an increased rate of revertants at 20 µg/plate in the presence of S9 liver fraction. It also shows genotoxic activity in Salmonella typhimurium TA102 at 1.25 µg/plate, resulting in a high number of revertants (Rvb = 327.8 ± 9.1) with an activity level of 843.0 in the presence of S9 liver extract..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-Aminofluorene (2-Fluorenamine) is a biochemical.
别名	2-氨基芴, 2-Fluorenamine

化学信息

分子量	181.23
分子式	C₁₃H₁₁N
CAS No.	153-78-6
Smiles	Nc1ccc-2c(Cc3ccccc-23)c1
密度	1.0941 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 245 mg/mL (1351.87 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5179 mL	27.5893 mL	55.1785 mL	275.8925 mL
5 mM	1.1036 mL	5.5179 mL	11.0357 mL	55.1785 mL
10 mM	0.5518 mL	2.7589 mL	5.5179 mL	27.5893 mL
20 mM	0.2759 mL	1.3795 mL	2.7589 mL	13.7946 mL
50 mM	0.1104 mL	0.5518 mL	1.1036 mL	5.5179 mL
100 mM	0.0552 mL	0.2759 mL	0.5518 mL	2.7589 mL