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Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Cat. No.	Product Name	CAS No.	Purity
T2618	LGK974 化合物LGK-974	1243244-14-5	99.16%
T2618	LGK974 是一种有效的、特异性的、具有口服活性的Porcupine(PORCN) 抑制剂(IC50:0.1 nM)。
T5342	IWP-O1 化合物IWP-O1	2074607-48-8	99.98%
T5342	IWP-O1 是Porcn抑制剂，在 L-Wnt-STF 细胞中的EC50值为 80 pM。它能够抑制Wnt蛋白分泌，可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
T2242	Wnt-C59 化合物Wnt-C59	1243243-89-1	99.91%
T2242	Wnt-C59 是一种高效的、口服具有活力的PORCN抑制剂(IC50:74 pM)。
T2702	IWP-2 化合物IWP-2	686770-61-6	99.76%
T2702	IWP-2 是一种 Wnt 加工和分泌抑制剂，IC50为 27 nM。它还是一种具有 ATP 竞争能力的CK1δ抑制剂，对于M82FCK1δ的IC50为 40 nM。在无细胞试验中，它可选择性阻断 Porcn 介导的 Wnt 棕榈酰化。
T2683	IWP L6 化合物IWP-L6	1427782-89-5	99.74%
T2683	IWP-L6 是一种高活性的Porcn抑制剂(EC50:0.5 nM)。
T4438	Porcn-IN-1 化合物Porcupine-IN-1	2036044-77-4	99.61%
T4438	Porcupine-IN-1 是一种有效的porcupine抑制剂(IC50:0.5±0.2 nM)。
T4043	ETC-159 化合物ETC159	1638250-96-0	99.4%
T4043	ETC159 是一种具有口服活性的，有效PORCN抑制剂。抑制β-catenin报告基因活性的IC50值为2.9 nM。
T11444	GNF-6231 化合物GNF-6231	1243245-18-2	100%
T11444	GNF-6231是一个强的，有选择性的，能够口服的Porcupine抑制剂能够阻止Wnt信号通路。