zanthoxylum

Ombuin 是一种从花椒中分离出的广谱抗菌剂，MIC 为 125 至 500 μg mL。

Xanthoxylin (Xanthoxyline) 是从Zanthoxylum simulans 中分离出来的是一种冰片和樟脑味化合物，有抗真菌和抗癫痫作用。

L-Citronellol ((S)-(-)-beta-Citronellol) 是一种从天竺葵中分离到的小分子化合物，具有抗真菌活性， 会对真菌膜产生影响。L-Citronellol 在对念珠菌酵母菌作用时与两性霉素B具有协同作用。

NITIDINE 是一种从花椒根中分离出来的具有生物活性的植物苯并菲啶生物碱。它具有抗癌、神经保护、抗疟疾、抗 HIV、镇痛、抗炎和抗真菌活性。

Hydroxy-Epsilon-Sanshool is an alkyl amide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensation.

Sanshool is a natural product isolated from Zanthoxylum bungeanum. Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy.

Sanshodiol是一种天然产物，属于芸香科花椒属，其产品编号为 T3833，CAS号为 54854-91-0。Sanshodiol可用作对照参考。

Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a concentration of 100 μM.3 Dietary administration of collinin (0.05% w/w) reduces the number of mice with tumors and the number of tumors per mouse in a mouse model of colitis-related carcinogenesis.4 |1. Kim, S., Seo, H., Al Mahmud, H., et al. In vitro activity of collinin isolated from the leaves of Zanthoxylum schinifolium against multidrug- and extensively drug-resistant Mycobacterium tuberculosis. Phytomedicine 46, 104-110 (2018).|2. Nguyen, P.-H., Zhao, B.T., Kim, O., et al. Anti-inflammatory terpenylated coumarins from the leaves of Zanthoxylum schinifolium with α-glucosidase inhibitory activity. J. Nat. Med. 70(2), 276-281 (2016).|3. I.S., C., Lin, Y.C., Tsai, I.L., et al. Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium. Phytochemistry 39(5), 1091-1097 (1995).|4. Kohno, H., Suzuki, R., Curini, M., et al. Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int. J. Cancer 118(12), 2936-2942 (2006).

Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。

(-)-Asarinin (Eleutheroside B4) 是一种主要从 Zanthoxylum armatum 根部提取到的木脂素。

Angoline hydrochloride (6-Methoxyldihydrochelerythrine) 是一种从 Zanthoxylum nitidum 中分离的选择性 IL-6 STAT3 信号通路抑制剂，具有抗癌活性，抑制 STAT3 信号传导，抑制 STAT3 磷酸化及其靶基因表达，抑制癌细胞增殖。

Dihydronitidine是从Zanthoxylum rhoifolium中提取的一种生物碱。

Hydroxy-α-sanshool 是分离自胡椒的烷基酰胺，作为 TRPA1的共价激动剂和 TRPV1的非共价激动剂，EC50分别为69和 1.1 µM。

Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells.

Hydroxy-β-sanshool 是一种从胡椒中提取的辛辣化合物。

Hydroxy-γ-sanshool is a pungent compound, it can cause oral numbness.

gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug ml, respectively. It has sister chromatid exchanges (SCEs)-inducing activity

Schinifoline 是从 Zanthoxylum schinifolium Sieb 中提取出来的一种喹啉酮衍生物，具有细胞毒性活性，可促进癌细胞放射敏感性，影响细胞循环周期和细胞凋亡。

Decarine has high antibacterial activity against mycobacterial, gram-positive and gram-negative bacteria, and low cytotoxicity towards human macrophages.Decarine inhibits fMLP CB-induced elastase release with IC(50) values < or = 5.53 microg mL.

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1 CaCC-mediated short-circuit currents in ANO1 CaCC-expressing FRT cells.

Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱，在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。

Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸 cytochalasin B（fMLP CB）产生的超氧阴离子有抑制作用。

2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2692，CAS号为 137809-97-3。

4-Methoxy-1-methylquinolin-2-one is a natural product from Zanthoxylum nitidum.