unc2025

UNC2025 (mrx-6313) 是高效的、具有口服活性的、ATP 竞争性的Mer Flt3双抑制剂，IC50值分别为 0.74 nM 和 0.8 nM。它对MERTK 的选择性比 Axl 高 45 倍(IC50:122 nM;Ki:13.3 nM)。它具有良好的 PK 特性，可用于研究急性白血病。

UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active Mer Flt3 inhibitor. It has IC50 values of 0.74 nM and 0.8 nM, respectively, for Mer and Flt3. UNC2025 hydrochloride demonstrates over 45-fold selectivity for MERTK compared to Axl (IC50 = 122 nM; Ki = 13.3 nM). Additionally, UNC2025 hydrochloride exhibits excellent PK properties, making it suitable for investigating acute leukemia.

UNC2025 2HCl (1429881-91-3(free base)) 是一种有效且具有口服生物利用度的 Mer Flt3 双重抑制剂，对 Mer Flt3 的 IC50 为 0.8 0.74 nM。