troleandomycin

Troleandomycin (Triacetyloleandomycin) 是一种大环内酯类抗生素，是具有口服活性和特异性的 CYP3A 抑制剂，可诱发记性感言，诱导长期胆汁淤积，可用于研究哮喘疾病。

AM679 是高效且选择性的 FLAP 抑制剂，其 IC₅₀ 分别为 2.2 nM（FLAP binding）、0.6 nM（hLA）及 154 nM（hWB）。AM679 具有改善的 CYP 抑制特性，无 CYP3A4 时间依赖性抑制或诱导，并在啮齿类 BAL 模型中口服给药后展现出强效体内白三烯抑制作用。

Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports of heart rhythm abnormalities and these led to 80 deaths. Other reported adverse effects are: headache, diarrhea, abdominal pain, nausea, constipation. Cisapride for animals has been found helpful in some cases of megaesophagus and is a common treatment for feline megacolon. Clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride. Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be e......