t-2513

T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis.

T-2513 hydrochloride 是拓扑异构酶 I (topoisomerase I) 的选择性抑制剂。T-2513 hydrochloride 能够共价结合拓扑异构酶 I-DNA 复合物，保持其稳定性，并能够抑制 DNA 复制和 RNA 合成，导致细胞死亡。

CVT-2513 is a metabolite of Renolazine, which has anti-myocardial ischemia effect.

Delimotecan is a DNA topoisomerase I inhibitor. Delimotecan had a long terminal half-life of 109 h, and relatively high exposures to T-2513 and SN-38 were obtained. The percentage decrease in WBC and absolute neutrophil count significantly correlated with