SulfoDBCO-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
3-Azidopropionic Acid Sulfo-NHS Ester is a water-soluble compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the p
SulfoDBCO-PEG3-acid 是一种具备叠氮基团的点化学试剂,是DBCO-acid的衍生物,它包含了一个PEG连接剂和DBCO基团.DBCO基团以其应变促进的高能量特性,经常被应用于无铜点击化学反应中.其亲水性的聚乙二醇链和硫基极大地提高了其水溶性.该化合物的末端羧酸在激活剂(如 EDC 或 HATU)存在下能与伯胺基团发生反应,生成酰胺键.该产品为试剂级,仅限研究使用.