sting agonist 1a

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)

STINGagonist-18（compound 1a）适用于ADCs的合成，例如与Trastuzumab偶联。

STINGagonist-35 (Compound 1a) 是干扰素基因刺激剂 (STING) 的激动剂，激活野生型 STING 和突变型 STING (R232H)，激活率分别为 99% 和 92%。STINGagonist-35 有潜力成为 ADC 药物的有效载荷。

STING agonist-18 diTFA (compound 1a) 是用于合成抗体活性分子偶联物 (ADCs) 的关键成分,例如用于Trastuzumab 偶联物的生产.