sk channel

Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。

SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1].

Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT， 通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。

ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) 是有效的 SK 通道抑制剂。ICA 显示出抗利什曼原虫的活性，IC50为2.1 µM。

NS8593 hydrochloride (NS8593 HCl) 是选择性的 SK 通道抑制剂。它可逆抑制 SK3介导的电流，Kd 值为 77 nM。它抑制所有 SK1-3亚型的 Ca2+依赖性 (在 0.5 μM Ca2+时，Kd 分别为 0.42、0.60 和 0.73 μM)，并且不影响中间电导和大电导的钙激活钾通道。

UCL-1848 trifluoroacetate salt is a selective Ca2+-activated, SK potassium channel blocker.

AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 μM. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF).

Bupivacaine is a BK SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells.

Tamapin为靶向小电导Ca(2+)激活的K(+) (SK)通道的毒液肽，尤以钾通道SK2为选择性阻断剂。该化合物能够抑制海马锥体神经元SK通道介导的电流，来源于印度红蝎(Mesobuthus tamulus)。

Tamapin TFA为靶向小电导Ca(2+)激活的K(+) (SK)通道的毒液肽，特异性抑制SK2（钾通道）并阻断海马锥体神经元中SK通道介导的电流。该化合物可从印度红蝎(Mesobuthus tamulus)毒液中提取。

Rimtuzalcap (CAD-1883) 是首创的，选择性的小电导钙激活钾通道 (SK 通道) 正变构调节剂。Rimtuzalcap 可用于运动障碍的研究，包括脊髓小脑性共济失调 (SCA)和特发性震颤 (ET)。