s-107 hydrochloride

S107 hydrochloride, a RyR-selective 1,4-benzothiazepine derivative, could stabilize RyR2 channels via enhancing the binding affinity of calstabin2 to mutant and or PKA-phosphorylated channels.

S107 是一种 RyR 选择性 1, 4-苯并硫氮杂卓衍生物，通过增强 calstabin2 与突变和/或 PKA 磷酸化通道的结合亲和力来稳定 RyR2 通道。