rip-2 kinase inhibitor 4

RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (with a pIC50 value of 8) and effectively inhibits the release of TNF-α.

Necroptosis-IN-4 作为一种 RIP 激酶 1 (RIPK1) 抑制剂,显示出了高效的坏死凋亡 (necroptosis) 抑制能力.该化合物对 RIPK3 不具备抑制活性,而对 VEGFR1 2 和 PDGFR-α 仅表现出弱抑制作用.

Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂，通过在激酶结构域中占据一个独特的结合口袋，将 RIPK1 激酶稳定在非活性构象中。