retwt

RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).

RET-IN-27 (compound 20p) 作为RET的高效抑制剂，在治疗癌症的研究中显现出关键作用，其对RETWT、RETV804L、RETV804M、RETM918T的IC50值分别为3.6 nM、0.1 nM、2.1 nM、0.3 nM。