ret in 3

RET-IN-3 是一种具有选择性和高效性的 RETV804M 激酶抑制剂，具有潜在抗癌活性,可用于研究非小细胞肺癌。

RETligand-3 是一种作为靶向RET的PROTAC QZ2135的配体。

Secretin (33-59), rat (Secretin (rat)) 是由 27 个氨基酸组成的多肽。Secretin (33-59), rat 可作用于分泌素受体，能够增强胰腺的碳酸盐、酶和钾离子的分泌。

Phloretin 3',5'-Di-C-glucoside 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124963。

Secretin (33-59), rat (TFA) 为含27个氨基酸的多肽，针对分泌素 (secretin) 受体具有特异性作用，主要促进胰腺分泌碳酸盐、酶及钾离子。

Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas[1][2].

(Rac)-Hesperetin 3'-O-β-D-glucuronide 是一种用于糖生物学研究的生化试剂。糖生物学的研究对象包括糖的结构、合成、生物学和进化，该领域涉及碳水化合物化学、聚糖的形成与降解酶学、蛋白质与聚糖的相互识别、以及聚糖在生物系统中的作用，同时它与基础研究、生物医学及生物技术密切相关。

Vandetanib Fumarate is an orally available tyrosine kinase inhibitor. Vandetanib Fumarate works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epidermal growth factor receptor and to a

QZ2135 (compound 20) 是一种针对RET的PROTAC降解剂，并在Ba F3-KIF5B-RET-G810C异种移植小鼠模型中展示了抗肿瘤特性。QZ2135对于KIF5B-RET的降解活性DC50为4.7 nM (WT)、17.2 nM (V804M)、73.8 nM (G810C)。该化合物由靶蛋白配体 (red part)RETligand-3、E3连接酶配体 (blue part)Lenalidomide-F和PROTAC Linker (black part)7-Iodohept-1-yne组成，其中靶蛋白配体和linker形成偶联物RETLigand-Linker Conjugate-1。

Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation. Ganglioside GM1acts as a receptor for cholera toxin, which binds to its oligosaccharide group, facilitating toxin cell entry into epithelial cells of the jejunum.4,5Similarly, it is bound by the heat-labile enterotoxin fromE. coliin the pathogenesis of traveler's diarrhea.6Ganglioside GM1gangliosidosis, characterized by a deficiency in GM1-β-galactosidase, the enzyme that degrades ganglioside GM1, leads to accumulation of the gangliosides GM1and GA1in neurons and can be fatal in infants.1Levels of ganglioside GM1are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson's disease.3Ganglioside GM1mixture contains a mixture of ovine ganglioside GM1molecular species with primarily C18:0 fatty acyl chain lengths, among various others. [Matreya, LLC. Catalog No. 1544] 1.Kolter, T.Ganglioside biochemistryISRN Biochem.506160(2012) 2.Mocchetti, I.Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophinsCell Mol. Life Sci.62(19-20)2283-2294(2005) 3.Ledeen, R.W., and Wu, G.The multi-tasked life of GM1 ganglioside, a true factotum of natureTrends Biochem. Sci.40(7)407-418(2015) 4.Turnbull, W.B., Precious, B.L., and Homans, S.W.Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetryJ. Am. Chem. Soc.126(4)1047-1054(2004) 5.Blank, N., Schiller, M., Krienke, S., et al.Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1Immunol. Cell Biol.85(5)378-382(2007) 6.Minke, W.E., Roach, C., Hol, W.G., et al.Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonistsBiochemistry38(18)5684-5692(1999)

PLM-101是一种口服抗癌剂，针对FLT3和RET具有选择性抑制作用，有效抑制急性髓系白血病（AML）细胞。通过抑制RET，PLM-101促使FLT3的自噬降解，并且通过抑制PI3K和Ras ERK信号通路来发挥其抗白血病的活性。在小鼠MV4-11侧翼异种移植模型中，PLM-101以口服剂量3及10 mg kg显示出抗肿瘤效果，并且在同种异种移植小鼠模型中，剂量为40 mg kg（口服）亦展现出明显的抗肿瘤功效。

RET-IN-25（化合物6b）是一种具有抗癌活性的RET激酶抑制剂。该化合物能够抑制甲状腺髓样癌（MTC），在TT(C634R) MTC细胞系中的IC50值分别为3.6 μM（3天）和3.0 μM（6天）。

Sulforhodamine 101 DHPE, a fluorescent probe, results from the conjugation of sulforhodamine 101, a red fluorescent dye with excitation emission spectra of 586 605 nm, to the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE. It effectively integrates into phospholipid bilayers and is utilized for imaging solid supported lipid bilayers, detecting protein-ligand interactions on bilayers, and monitoring lipid probe colocalization in liposomes through resonance energy transfer (RET).