raloxifene

Raloxifene (LY139481) 是一种选择性雌激素受体调节剂，在某些位点展现出雌激素激动剂作用和雌激素拮抗剂，具有抗病毒活性，可用于研究埃博拉病毒、甲型流感病毒和丙型肝炎病毒感染。

Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂，用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用，但对乳腺和子宫组织具有完全的雌激素拮抗作用。

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is an LRH-1 antagonist with an IC50 of 3.1 μM.

Raloxifene 4'-glucuronide, a primary metabolite of Raloxifene.

Raloxifene 6,4'-Bis-β-D-glucuronide, a metabolite of Raloxifene, acts as a selective antagonist of the estrogen receptor used for osteoporosis prevention.

Raloxifene 6-glucuronide, a primary metabolite of Raloxifene, is mediated predominantly by UGT1A1 and UGT1A8.

4-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is a compound resulting from the reaction of Raloxifene with tertbutyldimethylsilyl chloride.

Methyl Raloxifene 4'-(2,3,4-Tri-O-acetyl-β-D-glycopyranuronate) is a derivative compound of Raloxifene 4'-glucuronide, designed to resemble its structure and function.

Raloxifene Bismethyl Ether hydrochloride, a metabolite of Raloxifene, is an estrogen receptor inactive compound with both hydroxyl groups absent.

Raloxifene N-Oxide is a Raloxifene oxidative degradation product.

Compound 7, or Raloxifene 6-Monomethyl Ether, is a derivative of Raloxifene that effectively inhibits estrogen receptor α. It also displays the inhibitory effects on MCF-7 cells, with an IC50 of 250 nM and a pIC50 of 6.6.

Raloxifene 4-Monomethyl Ether (Compound 37) is a derivative of Raloxifene which acts as an inhibitor of estrogen receptor α. It effectively suppresses the activity of MCF-7 cells, exhibiting an IC50 value of 1 μM and a pIC50 value of 6.

Raloxifene dimethyl ester hydrochloride is an analog of Raloxifene.

4'-Raloxifene-β-D-glucopyranoside is a metabolite of Raloxifene. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist.

6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss, resorption, and lowering lipid

Raloxifene Bismethyl Ether, a Raloxifene metabolite, is an estrogen receptor inactive compound that lacks both hydroxyl groups.

Desketoraloxifene 是一种选择性雌激素受体调节剂，可抑制哺乳动物 PLD（PLD1 和 PLD2）。

LY88074是一种雷洛昔芬类似物，其基本侧链已被去除。LY88074是ERβ的激动剂(EC50 = 232 nM)。这种化合物刺激子宫细胞增殖。

LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.

Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) exhibiting a fixed ring structure analogous to raloxifene. This compound demonstrates potent antiestrogenic effects on breast cancer and endometrium while displaying minimal side effects. Additionally, Arzoxifene elicits favorable estrogenic effects on bone health and lipid profile.

LY117018 TFA，作为 Raloxifene 类似物，是一种选择性雌激素受体 (estrogen receptor) 调节剂，具有对乳腺癌细胞的抗增殖作用。

Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂，是水飞蓟素有效的抗纤维原性和抗低聚物成分，具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性 ，可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。